The family are creating an enormous jigsaw. After they realise a jigsaw piece is missing, the family look for it. Homer looks through Marge's memory box and sees a poster of Moe's Tavern's opening. But there is Marge's writing on it. It says Homer made it the worst day of her life because Homer, when he was a teenager, during the opening becomes drunk and ditches Marge so he can play Asteroids on an arcade machine with his friends. He is soon sent to the hospital with alcohol poisoning. This leaves Homer concerned why Marge stayed with him; he then finds a hospital appointment card dated two days later, confirming she was pregnant with Bart. When Homer confronts Marge about the letter, she says she was just upset that night, but is forced to admit that Homer did, and still does, things which annoy her. Homer then realizes Marge has been resenting him behind his back. The next day, they argue again and Homer leaves the house. He spends some time at Kirk Van Houten's apartment, but the generally depressive mood of the apartment complex where he lives drives him out. Homer then reads a newspaper saying that there is a place available. Finding out that the place is in Springfield's gay district, Homer moves in with a gay male couple, Grady and Julio. Homer has a visit home after taking Bart and Lisa out, but Marge and Homer still argue. At the gay bar, Homer tells Grady and Julio that his relationship with Marge is low.
The next day, Homer sees Marge and the kids, who have brought "Weird Al" Yankovic and his band, who play a song called "Homer and Marge", a parody of John Mellencamp's "Jack & Diane", to tell Homer that Marge loves him. Marge then asks Homer out on a date, but he is nervous while preparing for his date and drinks too much margarita. Meanwhile, at the venue of the date, Marge anxiously awaits Homer's arrival. When he arrives, she is upset that he is late and drunk, and leaves him. Back at the apartment, Grady tries to comfort Homer by telling him that he will find someone else, and kisses him romantically. Homer realises that Grady is in love with him and jumps out of the window, heading to Moe's Tavern to get some advice from Moe. Homer is about to come to the realisation that all of his problems are caused by alcohol when Moe forces beer down Homer's throat, giving him alcohol poisoning.
After Homer awakens, Dr. Hibbert tells him that the incident was not as bad as the night he first treated him for alcohol poisoning. Homer says it was the night that destroyed his marriage. Hibbert disagrees and plays a tape from the past of Homer's first alcohol poisoning. Marge says that she loves him in the tape. Marge appears and says she still does and they reconcile.
Years later, an elderly Dr. Hibbert is watching the tape and remarks that he made tapes because he suspected a nurse of stealing sponges. Then he sees her in the tape stealing sponges.