Bart, Milhouse and Homer line up at Comic Book Guy's store to purchase the first issue of a Radioactive Man reboot comic. Comic Book Guy finds out that his competitor Milo (the owner of Coolsville) is now married to his girlfriend, Strawberry. Comic Book Guy cries and sings a song about him being lonely his entire life. Suddenly, an imaginary Stan Lee appears to Comic Book Guy and tells him that he has another chance in love. A Japanese girl named Kumiko Nakamura enters the store, and Stan Lee advises Comic Book Guy not to waste the opportunity. Kumiko is in the US to do research about the country's saddest cities for her autobiographical manga. Comic Book Guy asks her out for a date, and then asks Homer for dating advice, since Homer is the only fat man in real life who is married to a hot woman. During the date, Marge advises Comic Book Guy to not be himself, but Kumiko actually likes Comic Book Guy's real personality.
Comic Book Guy continues to date Kumiko, and they both decide to move in together. While dropping off a gift for Kumiko and Comic Book Guy, Homer meets Kumiko's father in front of the store. Homer tells him about Comic Book Guy being an obese nerd, which prompts Mr. Nakamura to object to their relationship and take Kumiko away. Marge tells Homer to fix things up, so Homer takes Mr. Nakamura to a Japanese bar. They both drink Habushu (Snake Rice Wine), an incredibly strong form of rice wine (and Homer drinks what he thinks was fish wine when actually it was the restaurant aquarium) and stumble home intoxicated, where the city turns into a wonderland based on Studio Ghibli's films (specifically Spirited Away, My Neighbor Totoro, Ponyo, Princess Mononoke, Howl's Moving Castle, Kiki's Delivery Service, and Porco Rosso). Mr. Nakamura learns that by forbidding the relationship, he is taking away Kumiko's life.
Comic Book Guy tries to impress Mr. Nakamura by getting a real job using his hitherto unmentioned chemical engineering degree. Mr. Nakamura tells him that he does not have to get a real job since he already likes Comic Book Guy the way he is. The episode ends with Comic Book Guy and Kumiko getting married by Stan Lee in Comic Book Guy's store.