Ned Flanders invites the Simpson family to a barbecue party and announces his plans to open a store for left-handed people; The Leftorium. During the pulling of a wishbone, Homer, who has been constantly jealous of the material success of Ned and his family, wishes for The Leftorium to be a failure and go out of business. Homer ends up choking on a burger after his wish on the wishbone Homer frequently checks in on Ned to ensure that business is going poorly and is happy to see precisely that happening. When Homer sees left-handed citizens struggling with items made for right-handed people, he thinks about informing them about The Leftorium, but decides not to. Eventually the store does indeed close due to lack of business, plunging the Flanders' into debt and misery. Ned is forced to sell his possessions, and Homer gleefully buys many of Ned's things. Homer starts to regret what he did, but when he goes to return Ned's possessions, he finds Ned's house repossessed and the family living in their car. Homer wrestles with the guilt his wish has brought, and tells Ned to open the store for one final day. He then tells all the left-handed residents of Springfield about The Leftorium, and they all travel to the store and buy things. The increase in customers helps Ned keep the store open and get his house back.
In a subplot, Bart begins taking karate lessons at Akira's karate school. On his first lesson, he finds that karate is quite boring, so he decides to skip each lesson in order to play video games at the mall arcade. Whenever he is questioned by his family and friends about the techniques he has learned, he refers to the "Touch of Death", an ability he saw in one of the arcade games he played. He proceeds to terrorize his sister Lisa into doing his will by threatening her with the technique. His actions catch up to him when Lisa prods him to defend her from the school bullies and reclaim her saxophone. He ends up being pantsed and hung by his underwear from the basketball hoop rim by the bullies, as Lisa (having reclaimed her saxophone) wistfully notes that sometimes two wrongs do make a right.